Research
-
Cardiac Solid Mechanics
Arrow Up Right (link is external)Study how cardiac tissue deforms and responds to physiological conditions (e.g., exercise, pregnancy) and diseases (e.g., hypertension, myocardial infarction).
-
Computational Fluid Dynamics
Arrow Up Right (link is external)Analyze the flow of blood within the body. Fluid dynamics are essential in developing tissue-engineered vascular grafts, aneurysm formation, and congenital heart diseases.
-
Growth and Remodeling
Arrow Up Right (link is external)Understand and predict long-term tissue adaptation in regeneration and disease progression to identify patients at risk and enable personalized therapies.
Approach and tools
-
Finite Element Simulations
Arrow Up Right (link is external)Fuse multi-modal imaging data (e.g., MRI, CT, ultrasound) with measurements (e.g., blood pressure, ECG) to generate 3D continuum models of patients’ hearts and blood vessels.
-
Reduced Order Modeling
Arrow Up Right (link is external)Physics-based (e.g., 1D/0D fluid dynamics) and data-driven (e.g., Neural Networks, POD) models allow fast repeated model evaluations (e.g., optimization, parameter estimation).
-
Uncertainty Quantification
Arrow Up Right (link is external)Accounts for variations in input parameters and boundary conditions to quantify the reliability of our findings by providing probability distributions of our predictions.
Collaborators
- Daniel B. Ennis, Stanford University (Radiology)
- Jay D. Humphrey, Yale (Biomedical Engineering)
- Alison L. Marsden, Stanford University (Pediatrics - Cardiology)
- Wolfgang A. Wall, Technical University of Munich (Institute for Computational Mechanics)
Funding
We are currently supported by NIH K99/R00 award HL161313 ($1M, 2022-2027).